The activated NLRP3 recruits to pro-caspase-1, leading to the activation of caspase-1 [36], then the activated caspase-1 processes pro-IL-1β and pro-IL-18 for cleavage and processing, forming mature IL-1β and IL-18 and releasing them extracellularly [37, 38], exacerbating the inflammatory response [39–42], thus promoting the development and progression of NASH. Here, CASP1 is linked to metabolic dysfunction-associated steatohepatitis.