Further comparative analysis using TCGA and the Gene Expression Omnibus (GEO) databases showed that the expression level of PABPN1 was significantly lower in BC patients with higher pathological grade (Fig. 1H and Additional file 1: Fig S1E), muscle invasive diseases (Additional file 1: Fig S1F), and lymph nodes metastasis (Additional file 1: Fig S1G). The gene discussed is PABPN1; the disease is breast cancer.