By contrast, macrophages in rapidly growing tumors tend to adopt alternatively activated M2 phenotype, with release of IL-10 and expression of mannose and arginase1 (Arg1), resistin-like α (Fizz1), and chitinase-like 3 (Ym1), thereby promoting tumor cell proliferation, metastasis and angiogenesis [54]. Here, IL10 is linked to neoplasm.