Common TEAEs occurring in >5% of patients in any treatment group are detailed in Table 3; those occurring more frequently in the evinacumab versus placebo group included abdominal pain, headache, constipation, abdominal discomfort, increase in alanine aminotransferase/aspartate aminotransferase (defined as three times the upper limit of normal), back pain, contusion, dizziness, herpes zoster and sinusitis. The gene discussed is GPT; the disease is sinusitis.