Among the metabolic enzymes involved in D2HG and L2HG production (Fig. 5A) [19, 26–29], L2HGDH, ADHFE1, OGDH, and DLST were downregulated in CRC tissues from our transcriptome data (Fig. 5A, right) [18]. The gene discussed is ADHFE1; the disease is colorectal carcinoma.