CREB1 and Huntington disease: The pathways obtained using the down regulated genes involved include various neurodegenerative diseases like ALS, HD, PD, prions, spinocerebellar ataxia, proteasome and oxidative phosphorylation (Supplementary 2) The transcription factors involved include TAF1, BRCA, CREB, MYC, etc. (Supplementary 3 and 5).