The pathways obtained using the down regulated genes involved include various neurodegenerative diseases like ALS, HD, PD, prions, spinocerebellar ataxia, proteasome and oxidative phosphorylation (Supplementary 2) The transcription factors involved include TAF1, BRCA, CREB, MYC, etc. (Supplementary 3 and 5). This evidence concerns the gene TAF1 and Huntington disease.