The CHG analysis showed that abnormal expression of hub genes (EZH2, FLT1, IGF2, IRS1, JUN, KDR, SOX2, MYB, and ZEB1) might facilitate participating in pathways leading to the promotion of growth, sustained proliferation, resistance to apoptosis, induction of angiogenesis, activation of invasion, and metastasis, enabling replicative immortality, evading immune destruction, and tumor-promoting inflammation (Supplementary Table 8). Here, IRS1 is linked to neoplasm.