When age, gender, serum albumin, urinary protein, eGFR and IFTA score were adjusted at baseline, no difference in renal insufficiency rate was noticed between patients of MN alone and MN with diabetes (5.7 vs 14.7%, P > 0.05) Moreover, higher rate of proteinuria remission was achieved in MN without diabetes group at the end of follow-up (55.9% vs 29.4%, P = 0.027). This evidence concerns the gene ALB and Renal insufficiency.