DCTN1 and mild neurocognitive disorder: Knock-in (KI) and transgenic mice expressing MND-related G59S mutant p150Glued, as well as the Dctn1LoxP/LoxP;Thy1-Cre mice which lack the MTBDs-containing p150Glued but express p135+ in the forebrain and spinal neurons, have been generated22,27–29.