Considering their effect sizes, six (SETD1A, CUL1, XPO7, GRIA3, GRIN2A, and RB1CC1) out of the ten exome-wide significant genes were enriched for rare PTV and damaging missense (MPC > 3) variants with OR > 10, indicating that rare deleterious variants of these genes confer the schizophrenia risk with large effects as well as robust statistical significance. This evidence concerns the gene SETD1A and schizophrenia.