For high anxiety state assessment across all subjects in the independent test cohort, the best biomarker was ERCC6L2, decreased in expression in high anxiety, with an AUC of 68 % (p = 0.004) cross-sectionally, and an AUC of 69% (p = 0.03) longitudinally (Fig. 2A). The gene discussed is ERCC6L2; the disease is Anxiety.