To address this, we performed mIF assays and found that CD36+ CAFs showed more enrichment in the tumor core region than in the peritumor region in both human and mouse HCC tumors (Supplementary Fig. S3a, b), which was further validated in another HCC scRNA-seq database (GSE156625; Supplementary Fig. S3c, d)17 and through bulk RNA-seq18,19 using CIBERSORTx (Supplementary Fig. S3e). The gene discussed is CD36; the disease is hepatocellular carcinoma.