Although CD36+ CAFs were identified as a subtype of fibroblasts in murine HCC tumors, they highly expressed genes that were also found in hepatic stellate cells (HSCs), such as Lrat and Gfap31, rather than expressing the mesothelial cell markers Gpm6a and Msln and the portal fibroblast markers Ds and Entpd2, raising the possibility that CD36+ CAFs originated from HSCs (Supplementary Fig. S8b, c). This evidence concerns the gene MSLN and hepatocellular carcinoma.