ACOX1 and neoplasm: Importantly, the classification of CRC intrinsic-consensus molecular subtypes (iCMSs)37 based on TCGA transcriptomics showed that ACOX1 expression was significantly dysregulated in iCMS2 tumor samples, where β-catenin signaling is hyperactivated, relative to iCMS3 tumor samples (Supplementary Fig. S1e–g).