PTEN and brain ischemia: To elucidate the mechanism by which KLF10 inhibits cell proliferation, we studied the PTEN/AKT pathway activation by KLF10 in AKI mouse models and renal tubular epithelial cells, because mounting evidence suggests that PTEN/AKT pathway has great negative effects on cellular proliferation and cerebral ischemia-reperfusion injury [28, 34, 35].