Krüppel-like factor 10 (KLF10) is a well-known tumor suppressor of KLFs family because of its inhibitory effect on cell proliferation, and has become a research target for lung cancer, pancreatic cancer and liver cancer [26], which is first discovered as TGFβ inducible early gene 1 in osteoblasts [27]. The gene discussed is KLF10; the disease is liver cancer.