It is worthy to note that Cx3cr1‐Cre can sometimes evince haploinsufficiency in mouse models under pathological conditions, including LPS‐ or acute injury‐induced systemic inflammation, MPTP‐induced parkinsonism and the SOD1G93A model of amyotrophic lateral sclerosis.64, 65, 66. Here, CX3CR1 is linked to amyotrophic lateral sclerosis.