Although, at present, the molecular mechanism of how the deletion of microglial Tgm2 leads to reduced anxiety and increased cognitive deficits still remains elusive, we have identified the phagocytic genes, such as Cq1a, C1qb and Tim4, to be down‐regulated in Tgm2 cKO microglia compared with WT controls. This evidence concerns the gene TIMD4 and Cognitive impairment.