For example, the dose-dependent mean increase in MMP11 gene expression did not reach statistical significance in the POAG TM cell strains, and the mean increase in SSP1, ADAMTS8, and catenin-alpha 1 (CTNNA1) gene expression after exposure to 1000 μM bimatoprost was significant in the POAG TM cell strains, but not the normal TM cell strains. Here, ADAMTS8 is linked to open-angle glaucoma.