The pattern of changes in gene expression was generally similar in the POAG and normal TM cell strains, with the 1000 μM concentration of bimatoprost producing significant increases in MMP14, ICAM1, ITGA2, ITGA5, and LAMA3 mRNA levels, as well as significant decreases in ADAMTS1, contactin-1 (CNTN1), and catenin-delta 1 (CTNND1) mRNA levels, in TM cells derived from POAG eyes (Table 4) as well TM cells derived from normal eyes (see Table 1). The gene discussed is LAMA3; the disease is open-angle glaucoma.