For example, the dose-dependent mean increase in MMP11 gene expression did not reach statistical significance in the POAG TM cell strains, and the mean increase in SSP1, ADAMTS8, and catenin-alpha 1 (CTNNA1) gene expression after exposure to 1000 μM bimatoprost was significant in the POAG TM cell strains, but not the normal TM cell strains. This evidence concerns the gene MMP11 and open-angle glaucoma.