In a multivariate Cox regression analysis, the independent factors associated with IRIS events were the interval change of PVL at 1 month of ART (aHR, per 1 log decrease, 3.45; 95% CI, 1.52 to 7.81), a CD4-to-CD8 ratio of <0.1 at baseline (aHR, 3.47; 95% CI, 1.16 to 10.44), and ART initiation within 7 days of the IP diagnosis (aHR, 7.95; 95% CI, 1.04 to 60.90) (Table 2). This evidence concerns the gene CD8A and incontinentia pigmenti.