This type of treatment could be ideal in patients waiting for transplants (who are susceptible to aspergillosis) and in patients affected with advanced HIV infection (who are susceptible to cryptococcosis), because these fungal vaccines are effective in neutropenia (a condition that favors aspergillosis) and CD4+ T cell deficiency (a condition that favors cryptococcosis). Here, CD4 is linked to congenital T-cell immunodeficiency.