Also, a study on 59 colorectal carcinomas reported a significant overexpression of THRα1 in advanced-stage cancers compared to early-stage cancers (Uchuya-Castillo et al. 2018), similar to what we observed in ATC cells, that markedly upregulate THRα compared to nontumoral thyroid cells while inhibiting the THRβ transcription. This evidence concerns the gene THRB and cancer.