CGAS and neoplasm: Moreover, loss of cGAS and STING, as well as inhibition of the IL-6 receptor (IL-6R) were shown to specifically impair the outgrowth of chromosomally unstable TNBC tumours in vivo, suggesting that CIN imparts a tumour cell-intrinsic — if not an additional cell-extrinsic — dependency on cGAS–STING-driven IL-6/STAT3 signalling in primary TNBC cancers.