Principal component analysis was also applied on the multiple described histological parameters measured in each group (namely AF storage and CD68 immunoreactivity in cortex, thalamus, hippocampus, and cerebellum, and thickness of the cortical layer) with the aim of assessing the extent to which the different hPPT1‐LV HSPC delivery routes affected these parameters. Here, CD68 is linked to atrial fibrillation.