TARDBP and amyotrophic lateral sclerosis: TDP‐43 plays crucial role in human cancer through regulation of the oncogene or tumor suppressor mRNA splicing and stability.[48] Aberrant overexpression of TDP‐43 has been implicated in the pathogenesis of several types of human malignancies and tends to correlate with poor prognosis.[49] Meanwhile, the cytoplasmic aggregation of TDP‐43 has been observed in neurons of ALS and FTD patients.[50] Our findings revealed that RA specifically binds to TDP‐43, leading to mitochondrial TDP‐43 localization.