Previous studies have reported that RA efficiently suppresses proliferation, invasion and induction of apoptosis in various human carcinogenic cells through multiple cell signaling pathways, including Wnt/β‐catenin, JAK‐STAT, and PI3‐AKT signaling,[13, 37] however, whether RA may functions as an immune modulator and mediates its anti‐tumor efficacy remains unknown. This evidence concerns the gene AKT1 and neoplasm.