A very recent study found that inhibiting exosomal secretion in PTECs by knocking out Rab27a (a key exosome regulatory gene) could inhibit the excessive inflammatory response in PTECs through the miR‐26a‐5p/CHAC1/NF‐kB pathway, thereby delaying the progression of diabetic kidney disease,21 and another study reported similar findings, that inhibiting IRF‐1/Rab27a mediated exosome secretion accelerated albumin degradation, which could reverse tubule injury with albumin overload, and alleviate tubular inflammation by suppressing lysosomal degradation.22 Here, ALB is linked to diabetic kidney disease.