NLRP3 and cryopyrin-associated periodic syndrome: AIDs predominantly driven by gain-of-function mutations in one of the inflammasome platforms (e.g., NLRP3 inflammasome leading to cryopyrin-associated periodic syndrome [CAPS] or the pyrin inflammasome leading to familial Mediterranean fever [FMF]) commonly show high levels of IL-1β resulting from the immediate impact of the mutation on the function of the inflammasome (Sangiorgi and Rigante, 2022).