Disruption of the TNF pathways leads to TRAPS (migratory, erythematous patches and plaques), whereas various changes in the IFN pathways lead to AIDs, including CANDLE (lipodystrophy, violaceous plaques with raised borders, violaceous swellings of the lips and eyelids) or SAVI (violaceous, ulcerating plaques; facial erythema; telangiectatic lesions; tissue loss). This evidence concerns the gene TNF and lipodystrophy.