Laboratory findings during flares include leukocytosis, elevated acute-phase reactants (CRP, serum amyloid A, haptoglobin, fibrinogen), and an increased erythrocyte sedimentation rate (ESR) (Kastner, 2005; Shwin et al., 2017; Toro et al., 2000; Williamson et al., 1982). This evidence concerns the gene CRP and Increased total leukocyte count.