A novel SNV in the gene coding for the macrophage colony-stimulating factor (M-CSF), a known hematopoietic GF involved in the differentiation and stimulation of monocytes/macrophages, was associated with high levels of M-CSF in the plasma of patients with AOSD (Chen et al., 2020; Nemunaitis, 1993). This evidence concerns the gene CSF1 and adult-onset Still disease.