This finding in concussion, along with the perivascular location of chronically-deposited tau in CTE (McKee et al., 2014) support the theory that traumatic microvascular injury and release of blood components into brain parenchyma is important to the pathophysiology of tauopathy after TBI (Michalicova et al., 2017; Sandsmark et al., 2019). The gene discussed is MAPT; the disease is tauopathy.