SERINC5 and COVID-19: Moreover, we have confirmed that reduction of SERINC5 mRNA levels during SARS-Cov2 infection also occurred in VeroE6 and HEK293T-hACE2 cells (Figure 4), mainly at late stage, and in COVID-19 patient samples (Figure 1).Therefore, these data suggest that SARS-CoV-2 infection counteracts SERINC5 protein activity by protein 7a in the first stage and SERINC5 mRNA/protein levels at late stage by repression in the expression of this gene, highlighting the importance of the host factor in virus restriction.