Four dermatopathologists reviewed the histology of melanomas from individuals with germline variants in POT1 (n = 30 melanomas, 17 individuals), TERF2IP (n = 4 melanomas, 3 individuals), ACD (n = 4 melanomas, 2 individuals), and TERT (n = 2 melanomas, 2 individuals). This evidence concerns the gene POT1 and melanoma.