AMPK activation during low energy states leads to upregulation of energy generating processes and inhibition of energy-intensive processes involved in cyst expansion such as indirect inactivation of mTORC1 (Inoki et al., 2003; Gwinn et al., 2008) and inhibition of CFTR chloride channel, thus suppressing epithelial fluid and electrolyte secretion (Caplan, 2022). This evidence concerns the gene CFTR and cyst.