It is well known that TRPV1 activation in cancer cells such as urothelial, endometrial, and colorectal cancer cells, by strongly enhancing [Ca2+]i, promotes mitochondrial depolarization and ROS overproduction that leads to apoptotic cell death (Amantini et al., 2009; Fonseca et al., 2018; Hou et al., 2019). The gene discussed is TRPV1; the disease is cancer.