TRPV1 and chronic myelogenous leukemia, BCR-ABL1 positive: In addition, we also found that phospho-ubiquitin (Ser65) levels, correlated with injured mitochondria (Hepowit et al., 2022), are strongly enhanced in OLDA-treated CML cells (Figure 2F), supporting that OLDA, by triggering TRPV1, induces oxidative stress and mitochondrial dysfunction.