Moreover, the [Ca2+]i overload was associated with a clear rise in ROS production induced by OLDA in a TRPV1-dependent manner as shown by the evident increase in DCFDA fluorescence in siGLO but not in siTRPV1 CML cells (Figure 2C; Supplementary Figure S4A). The gene discussed is TRPV1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.