CD44 and melanoma: It was shown that ADAM10 or ADAM17-mediated cleavage of CD44 is triggered upon different stimulation e.g., by Ca2+ influx or protein kinase C (PKC) activation (Nagano et al., 2004), whereas a study on melanoma cells indicated that constitutive and endogenous shedding of CD44 is mediated by ADAM10 (Anderegg et al., 2009).