KLRB1 and neoplasm: Microglia-derived GAMs were predominant in newly diagnosed tumors, but were surpassed by more heterogeneous MDMs in the recurrent ones, especially in the hypoxic tumor environment.51 Regarding T cells, Mathewsonet al. showed that the inhibitory natural killer (NK) cells receptor CD161 is expressed in tumor-infiltrating lymphocytes, but absent in T regulatory cells (Tregs) or patient-matched peripheral blood mononuclear cells (PBMCs).