In the present study, we found that the immune targets PD-1, TIM-3, LAG-3, and GAL-9 were widely expressed in the TIIs of GTN patients but not associated with the patients’ prognoses, excepting that the positive expression of LAG-3 was a prognostic factor for disease recurrence. The gene discussed is LGALS9; the disease is gestational trophoblastic neoplasm.