To assess whether improved AT metabolic health caused by adipocyte HIF1α inactivation would have beneficial effects on muscle health in the setting of sarcopenic obesity, we generated a mouse model in which adipocyte Hif1a was inactivated in a doxycycline (DOX)-inducible manner (Figure 2B). Here, HIF1A is linked to obesity due to melanocortin 4 receptor deficiency.