Those from herbs caused anti-aging effects on ovariectomy or D-Gal-induced mice (18, 68, 84) and AD model APP/PS1 mice (167), through elevating mRNA and protein expressions of nuclear Nrf2, Nrf2, HO-1 and NQO1 in hippocampal, brain, and liver tissues, and reducing mRNA and/or protein expressions of Keap1 and cytosol Nrf2 in brain tissues. Here, HMOX1 is linked to Alzheimer disease.