NFE2L2 and major depressive disorder: In the past few decades, regulations of NPs on Nrf2 antioxidant pathway have been extensively studied in their health-promoting effects, such as liver protection (14), antioxidant (15), gastrointestinal protection (16), anti-diabetic (17), anti-aging (18), cardioprotection (19), lung protection (20), kidney protection (21), neuroprotection (22), anti-inflammation (23), immunomodulation (24), anti-depression (25), anti-cancer (26), improving reproductive function (27), anti-radiation (28), and anti-atherosclerosis (29).