Animals experiments have demonstrated that NPs from herbs could regulate Nrf2 antioxidant pathway for liver protection (14, 36, 41, 54, 57, 67, 116, 120, 147–153), kidney protection (21, 59, 154–157), lung protection (20, 158), neuroprotection (22, 121), cardioprotection (124, 159), gastrointestinal protection (16, 40, 48, 127, 128, 160, 161), anti-oxidation (15, 47, 162–164), anti-diabetic (56, 58, 135, 146, 165, 166), anti-aging (18, 68, 84, 167), anti-inflammation (23), anti-depression (25), anti-cancer (168), and improving reproductive function (169, 170), as implied in Table 1. Here, NFE2L2 is linked to major depressive disorder.