Polysaccharides from Inonotus obliquus (196), Amanita caesarea (109) and Hericium erinaceus mycelium (110) revealed anti-aging activity on AD model APP/PS1 mice via elevating protein expressions of Nrf2, SOD-1, HO-1, and GCLC, and reducing Keap1 protein expression in brain tissues or hippocampus. The gene discussed is KEAP1; the disease is Alzheimer disease.