Known collectively as the ‘tubulinopathies’, this disease spectrum encompasses numerous neurodevelopmental disorders including, microcephaly, lissencephaly, and polymicrogyria, reflecting the large number of tubulin genes expressed during embryonic brain formation (e.g., TUBA1A, TUBB2A, TUBB2B, TUBB3, TUBB5) (Keays et al., 2007; Jaglin et al., 2009; Poirier et al., 2010; Breuss et al., 2012; Cushion et al., 2014; Romaniello et al., 2018). The gene discussed is TUBA1A; the disease is lissencephaly spectrum disorders.