TUBB3 is a neuron-specific tubulin isotype (Cleveland, 1987; Joshi and Cleveland, 1989), and TUBB3 mutations typically cause structural brain malformations and/or congenital fibrosis of the extraocular muscle 3 (CFEOM3), an axon guidance disorder affecting the muscles that control the eye (Poirier et al., 2010; Tischfield et al., 2010). This evidence concerns the gene TUBB3 and cerebral malformation.