Furthermore, among the many identified miRNAs involved in metabolism and metabolic diseases, miR-122-5p, miR-34a-5p, and miR-125b-5p possess specific expression patterns and functions associated with obesity, insulin resistance and inflammatory states (Li et al., 2011; Yang et al., 2012; Zhu and Leung, 2015; Cai et al., 2020). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.