GCKR and metabolic dysfunction-associated steatotic liver disease: In addition, in a study using a human iPSC-derived liver organoid panel from 24 individuals with/without risk SNPs for NAFLD identified through a genome-wide association study (GWAS), GCKR (rs780094 C>T) was shown to be the SNP most strongly correlated with fat accumulation (Kimura et al., 2022).