In one subject, estimated glomerular filtration rate decreased from 85 mL/min/1.73 m2 to 52 mL/min/1.73 m2), serum albumin decreased from 4.2 g/dL to 2.0 g/dL, and the other subject experiencing grade 2 ileus had neutrophilia of up to 2.7 × 1010/L. The gene discussed is ALB; the disease is ileus.