When IL-22 and IL-33 concentrations were stratified according to age group (18–39 vs. 40–65 years), sex (male vs. female) or BMI (normal-weight vs. overweight/obese) in COVID-19 patients, only normal-weight patients showed significantly higher IL-22 concentrations than in overweight/obese patients (19.2 [IQR: 18.1–19.5] vs. 18.5 [IQR: 17.9–19.2] pg/mL; p = 0.04). Here, IL22 is linked to COVID-19.