Median IL-22 and IL-33 concentrations were significantly elevated in COVID-19 patients compared with HC (IL-22: 18.6 [IQR: 18.0–19.3] vs. 13.9 [IQR: 12.1–14.9] pg/mL, p < 0.001); IL-33: 37.8 [IQR: 35.3–43.0] vs. 24.1 [IQR: 23.0–26.2] pg/mL, p < 0.001) (Fig. 2). The gene discussed is IL33; the disease is COVID-19.