MAPT and Alzheimer disease: The pathology of AD involves the accumulation of extracellular amyloid-β (Aβ) plaques in the cerebral cortex and intracellular tau-containing neurofibrillary tangles that occur sequentially in the locus coeruleus, entorhinal cortex, hippocampus, amygdala, temporal lobe, basal forebrain and isocortical association areas (Torok et al., 2018).