In particular, phosphorylated PERK and phosphorylated eIF2α were significantly increased in postmortem brain tissue of patients with Alzheimer’s disease (AD; Chang et al., 2002; Hoozemans et al., 2005; Lourenco et al., 2015), and similar results were reported in several AD animal models (Devi and Ohno, 2010, 2014). This evidence concerns the gene EIF2A and Alzheimer disease.