In particular, phosphorylated PERK and phosphorylated eIF2α were significantly increased in postmortem brain tissue of patients with Alzheimer’s disease (AD; Chang et al., 2002; Hoozemans et al., 2005; Lourenco et al., 2015), and similar results were reported in several AD animal models (Devi and Ohno, 2010, 2014). The gene discussed is EIF2AK3; the disease is Alzheimer disease.