The ALS-associated SOD1 mutation induces several pathological features, such as oxidative stress (Ferrante et al., 1997), mitochondrial dysfunction (Mattiazzi et al., 2002; Damiano et al., 2006), and prion-like propagation of disease proteins (Grad et al., 2014). Here, SOD1 is linked to amyotrophic lateral sclerosis.