In addition, other neurodegenerative diseases, such as prion disease (Moreno et al., 2012), ALS (Saxena et al., 2009), Parkinson’s disease (Colla et al., 2012) and Huntington’s disease (Leitman et al., 2014), have been associated with the activation of PERK. The gene discussed is EIF2AK3; the disease is amyotrophic lateral sclerosis.