In the context of this mini-review, we have highlighted recent advances supporting the implication of prominent ER and cytosolic Ca2+ regulators (i.e., SERCA2, IP3Rs, RyRs, PVALB, NNAT) in the neurobiology of brain disorders with a strong neurodevelopmental component (Figure 1 and Table 1). The gene discussed is PVALB; the disease is brain disorder.