Interestingly, dysfunction of endoplasmic reticulum (ER) Ca2+ regulators such as the sarco-ER Ca2+ ATPase 2 (SERCA2), which sequesters cytosolic Ca2+ into the ER, and the Ca2+-releasing channels inositol triphosphate receptors (IP3Rs) and ryanodine receptors (RyRs) have recently garnered interest in the pathophysiology of brain disorders (Britzolaki et al., 2018, 2020). Here, ATP2A2 is linked to brain disorder.