NNAT and Angelman syndrome: Neuronatin (NNAT) is a developmentally regulated ER resident protein and negative regulator of SERCA that is expressed in the brain’s PVALB + GABAergic neurons; NNAT has also been implicated in abnormal neurodevelopment, including ASD and Angelman Syndrome (AS) (Pitale et al., 2017; Vatsa et al., 2019).