DCX and Alzheimer disease: Even at early stages of Braak staging, when the levels of Aβ and neurogenic fiber tangles accumulation were low, the expression of DCX, SOX2, and MAP2A in the hippocampus were decreased dramatically in AD patients compared with the control group, indicating downregulation of hippocampal neurogenesis (Li et al., 2008; Crews et al., 2010).