While NeuroD1 was shown to be an important target for repairing neuronal differentiation defects in the brains of AD patients, its overexpression promotes the transcription of genes related to neuronal differentiation, facilitating neuronal maturation and effectively improving spatial memory deficits in AD mice (Richetin et al., 2015; Pataskar et al., 2016). The gene discussed is NEUROD1; the disease is Alzheimer disease.