Furthermore, increased levels of pIRS1Ser636 and pGSK3βSer9, and hyperactivation of the Akt/mTOR/p70S6K pathway was reported in neuronal-derived extracellular vesicles from patients with Down syndrome (Perluigi et al., 2022) with an increased risk of AD (Zigman and Lott, 2007). This evidence concerns the gene MTOR and Alzheimer disease.