A study of ADHD-susceptible variants by Li et al. (2022) identified genes corresponding to single-nucleotide variants labeled as possibly or probably damaging including CACNA1H, PKD1, DYNC2H1, LRP6, and RGS11. The CACNA1H gene encodes for the α1-subunit of the T-type low voltage-dependent calcium (Ca2+) channel Cav3.2 (Leresche and Lambert, 2017), and mTORC1 pathway regulation may be driven by intracellular Ca2+ levels (Li et al., 2016). The gene discussed is LRP6; the disease is attention deficit-hyperactivity disorder.