LRP6 and attention deficit-hyperactivity disorder: In a mouse model overexpressing the thyroid hormone-responsive protein with defining characteristics of ADHD, a proteomic analysis of the hippocampus found an altered network of proteins involved in Wnt signaling; catenin β1 was found to be upregulated, and hippocampal gene expression of Wnt ligands, inhibitors, receptors, and co-receptors: i.e., significant reductions of the Wnt7a gene, as well as upregulation of Wnt inhibitors Dkk4 and Igfbp5 and enhanced Lrp6 expression was found (Custodio et al., 2023).