The STZ-icv model is characterized by a chronic and progressive cognitive decline (Knezovic et al., 2015) (AD face validity) accompanied by neuropathological and metabolic hallmarks of AD [i.e., BIR state (Grünblatt et al., 2007), neuroinflammation (Knezovic et al., 2017), accumulation of Aβ (Salkovic-Petrisic et al., 2011), hyperphosphorylated Tau (Li et al., 2020), mitochondrial dysfunction (Correia et al., 2011), oxidative stress (Sharma and Gupta, 2001), and glucose hypometabolism (Knezovic et al., 2018)] (AD construct validity) (Salkovic-Petrisic et al., 2021). Here, MAPT is linked to Alzheimer disease.