AKT1 and type 2 diabetes mellitus: Recently, a polygenic risk score (PRS) for T2DM was found to predict the conversion of amnestic mild cognitive impairment (MCI) to sAD, with shared genes highly expressed in cortical neurons; neuronal development and generation, cell junction and projection, and phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) and mitogen-activated protein kinase (MAPK) signaling pathway (Yang et al., 2022).