APP and Alzheimer disease: The evidence supporting this hypothesis comes from relatively rare longitudinal studies on ADHD models with behavioral follow-up after dissipation of the hyperactive phenotype (Dellu-Hagedorn, 2006), and the studies on AD that focus on the developmental/early aspect of AD-like pathophysiology that resembles ADHD e.g., overexpression of APP during brain development (Rodgers et al., 2012).