In particular, keeping in mind all the above and the recent literature proposing normalization of altered Wnt/mTOR signaling as a novel mechanism of action for MPH used as ADHD-treatment, the accumulated evidence provide a convincing argument and an encouragement to explore the idea that a timely introduction of ADHD therapy may delay/prevent neurodegeneration and cognitive decline in AD. The gene discussed is MTOR; the disease is attention deficit-hyperactivity disorder.