Recent evidence suggests the dysregulation of the Wnt/mTOR signaling pathways as a potential common mechanism in the etiopathogenesis of both ADHD and AD (Boonen et al., 2009; Inestrosa and Varela-Nallar, 2014; Tramutola et al., 2015; Tapia-Rojas and Inestrosa, 2018; Yde Ohki et al., 2020; Perluigi et al., 2021; Nagu et al., 2022; Narvaes and Furini, 2022). The gene discussed is MTOR; the disease is Alzheimer disease.