The well-known neuropathological hallmarks of AD are an accumulation of misfolded proteins, amyloid β (Aβ) in the forms of extracellular plaques and hyperphosphorylated Tau protein in the form of neurofibrillary tangles, accompanied by synaptic loss (Sanabria-Castro et al., 2017; Table 1). The gene discussed is MAPT; the disease is Alzheimer disease.