Furthermore, since GSK3β is the main kinase involved in the phosphorylation of the Tau protein (Hernandez et al., 2013), a convincing body of evidence indicates that hyperactivity of GSK3β is linked to pathological Tau hyperphosphorylation (Llorens-Martin et al., 2014), thus supporting a link between dysfunctional Wnt/β-catenin signaling with the two major AD hallmarks (Jia et al., 2019). This evidence concerns the gene MAPT and Alzheimer disease.