Furthermore, increased levels of pIRS1Ser636 and pGSK3βSer9, and hyperactivation of the Akt/mTOR/p70S6K pathway was reported in neuronal-derived extracellular vesicles from patients with Down syndrome (Perluigi et al., 2022) with an increased risk of AD (Zigman and Lott, 2007). The gene discussed is AKT1; the disease is Alzheimer disease.