H19 and glioblastoma: Moreover, we demonstrate that H19, an imprinted lncRNA known to inhibit the function of an RBP capable of promoting circHomer1 biogenesis, is significantly up-regulated in male adult frontal cortex and displays a developmental- and brain region-specific expression that is opposite to what is observed for circHomer1. Lastly, we show that knockdown of H19 results in a significant up-regulation of circHomer1 in human glioblastoma cell lines.