This sucrose accumulation could further be prevented by manipulating another key enzyme, UGPase, since it has significant control over the flux of carbon toward sucrose biosynthesis and found to play a crucial role during CIS (Zrenner et al., 1993; Spychalla et al., 1994; Hill et al., 1996; Bagnaresi et al., 2008; Chen et al., 2008). Here, UGP2 is linked to in situ carcinoma.