KCC2 has an important role in maintaining neuronal chloride homeostasis and has been found to be associated with many severe neurological, psychiatric and neurodegenerative disorders, including epilepsy, neuropathic pain, schizophrenia, autism spectrum disorders and Parkinson's disease (Ben-Ari, 2017, Silayeva et al., 2015). This evidence concerns the gene SLC12A5 and autism spectrum disorder.