Early expression of NSs after infection would be important for robust RVFV replication, as the incoming viral RNPs can trigger type I IFN induction (Weber et al., 2013) and NSs suppresses host innate immune responses, including type I IFN induction by inhibiting IFN-β mRNA transcription (Le May et al., 2008). This evidence concerns the gene IFNB1 and infection.