Contemporary RNA-based antisense oligonucleotides and small interfering RNA’s for apoC3 and the angiopoietin-like 3 (ANGPTL3) profoundly attenuate plasma triglyceride in familial chylomicronemia, severe hypertriglyceridemia, dyslipidemia and T2DM (54). Here, ANGPTL3 is linked to type 2 diabetes mellitus.