It was reported that matrix metalloproteinase-1 (MMP1) (55), N-cadherin (48), E-cadherin (48), Epcam (48), CDK6 (49), RHOU (49), INSM1 (50) and RASSF10 (51) within the serum exosomes are elevated in invasive NFPA patients compared with noninvasive NFPA patients. This evidence concerns the gene RHOU and non-functioning pituitary adenoma.