It was reported that matrix metalloproteinase-1 (MMP1) (55), N-cadherin (48), E-cadherin (48), Epcam (48), CDK6 (49), RHOU (49), INSM1 (50) and RASSF10 (51) within the serum exosomes are elevated in invasive NFPA patients compared with noninvasive NFPA patients. Here, CDH1 is linked to non-functioning pituitary adenoma.