It was reported that matrix metalloproteinase-1 (MMP1) (55), N-cadherin (48), E-cadherin (48), Epcam (48), CDK6 (49), RHOU (49), INSM1 (50) and RASSF10 (51) within the serum exosomes are elevated in invasive NFPA patients compared with noninvasive NFPA patients. The gene discussed is CDH2; the disease is non-functioning pituitary adenoma.