INSM1 and non-functioning pituitary adenoma: It was reported that matrix metalloproteinase-1 (MMP1) (55), N-cadherin (48), E-cadherin (48), Epcam (48), CDK6 (49), RHOU (49), INSM1 (50) and RASSF10 (51) within the serum exosomes are elevated in invasive NFPA patients compared with noninvasive NFPA patients.